A Stability Indicating RP-HPLC Method for Simultaneous Estimation of Acebrophylline, Montelukast, and Fexofenadine in Bulk and Pharmaceutical Dosage Forms

Introduction: The goal of the current work is to create an RP-HPLC method for quantitative analysis Acebrophylline, Montelukast, and Fexofenadine in Pharmaceutical dosage form. Materials Methods: Chromatographic separation Montelukast was executed on Waters Alliance-e2695, by using Hyper clone 5μ BDS C18 130A (250 x 4.6mm) column mobile phase consisting Methanol: Ammonium formate adjusted pH-6 ortho phosphoric acid (70:30). flow rate: 1.0 mL/min, Column temperature: 25°C detection wavelength 268nm utilizing a photodiode array detector. Results Discussion: According ICH criteria, new approach validated, forced degradation tests are also carried out. procedure effective precise identification quantification three medicines relation all revealed validation factors. technique shows be suitable identifying chemical degradation. Conclusion: Therefore, created can utilized quality control routine laboratory these particular medications.